- Sample complexity reduction
- Abundant protein depletion
- 2DE electrophoresis analysis
- Western blotting
- Preparative IEF
- Protein array chemistry and content selection
- In-gel digest and MALDI-MS
- Commercial product development
- Automation
MOLECULAR BIOLOGY
- DNA/RNA isolation from clinical samples
- PCR and Real time qPCR
- Detection of contaminating NA in process samples
- Detection of rare cells in clinical samples
- Primer design and database searching
- Oligonucleotide synthesis
- Hybridization kinetics and array hardware design
CHROMATOGRAPHY
- Design of IEX and affinity media and manufacture
- Production of MAb at cGMP scale
- Ligand coupling to activated supports
- Production of Protein A and thiophilic affinity supports
- Sample complexity reduction for Biomarker Discovery
- Abundant protein removal
- Interface with MALDI-MS and LC-MS/MS
CHEMISTRY
- Surface modification of membrane surfaces
- Formation of particles
- Activation chemistries
- Peptide coupling under cGMP
- Coating of magnetic particles for surface activation
- Understanding of aqueous hydrogel polymerization
- IPG strip manufacture
- Pre-cast SDS-PAGE manufacture
- Affinity ligand synthesis at production scale
- Protein A supports
- Thiophilic ligands
- Small scale organic synthesis of unique monomers
- Custom solid phases for oligonucleotide synthesis
- Polymer surface modification for MALDI-MS applications